ea0013p335 | Thyroid | SFEBES2007
McDonald David
, Gora Monika
, Lakey Jeremy
, Pearce Simon
The mechanism by which the thionamide antithyroid drugs produce long-term remission of GravesÂ’ hyperthyroidism is unknown. We wished to explore the hypothesis that methimazole (MMI) could induce a structural change in thyroid peroxidase (TPO), such that its major (immunodominant) epitope(s) was no longer recognised by circulating anti-TPO antibodies.An enzymatically active membrane preparation of a CHO cell-line stably transfected with human TPO was...